Psoriasis is a condition in which the human immune system mistakenly attacks healthy skin cells. As a result, scaly plaques appear on its surface, which can cause severe itching and even pain. Sometimes the disease is also accompanied by inflammation of the joints and eyes.
What is psoriasis
Psoriasis is a chronic autoimmune disease that causes red, scaly patches to appear on the surface of the skin. They are often called plaques.
Psoriasis cannot be infected – it is an autoimmune and non-infectious disease.
Psoriasis is manifested by inflammation of the skin, as well as abnormally rapid growth and exfoliation of cells (keratinocytes) that make up the stratum corneum - the epidermis. Normally, it is completely renewed within a month, but in people with psoriasis this process is often accelerated and occurs on average in 3–4 days.
In addition to damage to the skin, the disease causes joint inflammation (in about 30% of cases). A little less frequently - in 10% of cases - psoriasis leads to inflammation of the uvea (uveitis).
Prevalence of psoriasis
Psoriasis most often affects people between 15 and 35 years old, but in general the disease can appear at any age. The first peak of the onset of pathology occurs at 15-20 years, the second at 55-60.
On average, psoriasis affects approximately 1–2% of people worldwide. In our country, according to the clinical recommendations of the Ministry of Health, in 2021 the prevalence of the disease was 243. 7 cases per 100 thousand inhabitants.
Types of psoriasis
Like many chronic diseases, psoriasis differs by stages, severity and form of manifestation.
By stage
Psoriasis has three stages: progressive, stationary and regression (remission) stages.
INprogressive stagered spots appear on the skin. Merging together, they form large scaly plaques with a pronounced red outline at the edges - it is called erythema Erythema Redness of the skin caused by dilation of capillaries and blood flow. corolla or corolla. New plaques are very itchy and can hurt.
Traumatized areas of the skin are especially susceptible to the appearance of new spots: a psoriatic plaque can quickly develop at the site of friction (for example, on clothing), as well as in the area of a scratch or scratch. Doctors call this phenomenon the Koebner phenomenon.
This phenomenon, also known as "isomorphic reaction", was discovered by the German dermatologist Heinrich Koebner in 1872. The doctor noticed that in some patients with psoriasis new plaques appear on the skin in places of trauma, for example after scratching, injections or bruises.
Stationary stage- stabilization phase. The plaques stop growing, but continue to bother and flake off. New rashes and blemishes usually do not appear.
Regression stageoccurs when psoriasis symptoms begin to disappear. The peeling disappears, the plaques become lighter and flatter. Symptoms subside at this stage.
By gravity
To assess the severity of psoriasis, doctors use the PASI (Psoriasis Area and Severity Index) system - an index for assessing the severity and prevalence of psoriasis. It requires a professional analysis of parameters such as severity of erythema, infiltration, peeling and calculation of the area of skin affected by rashes.
Depending on the results of the examination, doctors distinguish between mild, moderate and severe degrees of the disease.
According to the form
According to the clinical picture of manifestations, several main forms of psoriasis are distinguished: vulgar, inverse, seborrheic, exudative, guttate, pustular, psoriasis of the palms and soles and psoriatic erythroderma.
Psoriasis vulgaris (common)- one of the most common forms, responsible for around 90% of all cases of the disease. First, red spots appear on the skin, which within a few days turn into convex, scaly plaques. As the plaques develop, they merge into large, scaly, itchy lesions. Then the condition enters the stabilization and regression phase: the manifestations of the disease temporarily decrease and the person's well-being improves.
The most common places where psoriasis vulgaris appears are the extensor (outer) part of the skin on the elbows and knees. Lesions also appear on the body and scalp.
Psoriasis vulgaris on the outside of the elbow
Inverse ("reverse") psoriasisproceed in the same way as usual. The only difference is in the location of the lesions: they appear not in the extensor (outer) part of the knees and elbows, but in the flexor (inner) part – that is, under the knee, under the armpits and in the elbow area, as well as on the neck. , eyelids, navel, inguinal folds. The skin in these areas is more delicate, moist and rubs against clothes more frequently. Therefore, it may itch more than in the usual form of the disease, but the peeling in these places is less pronounced.
Seborrheic psoriasisit proceeds in the same way as normal, but its foci are located in places with a large number of glands that secrete sebum. This is the scalp, folds behind the ears, cheeks and nasolabial region of the face, forehead, chest and back (mainly the upper part).
Seborrheic psoriasis on the scalp
Exudative psoriasis- type of disease in which, in addition to scaling, exudate also appears in the lesion. It is a fluid that contains proteins, some blood cells and other substances. Exudate can be released from capillaries during inflammation.
The crust on the surface of the plaques in the exudative form of the disease is usually dense, grayish-yellow, and sometimes slightly moist. This type of psoriasis appears more frequently in people with endocrine disorders: thyroid pathologies, type 2 diabetes mellitus or obesity.
Guttate psoriasisIt does not appear as plaques on the skin, but as numerous papules - swollen, bright red spots with scaling in the center. The size of the papules can vary from approximately 1 to 10 mm. They mainly cover the torso, arms and legs.
Guttate psoriasis often occurs in children following streptococcal infections (e. g. , tonsillitis). It is treated a little better than other types of psoriasis, but in some cases it can progress to the common (vulgar) form.
pustular psoriasischaracterized by the appearance of multiple pustules on a red erythematous background. Pustules are formations that look a lot like pimples. This psoriasis can be a consequence of infectious diseases, stress, hormonal imbalance, inappropriate use of medications or inappropriate use of ointments. Initially, numerous pustules appear on the red patches. They then merge into one large purulent spot (or "purulent lake").
The generalized form of pustular psoriasis is difficult to tolerate: with episodes of fever, weakness, as well as severe pain and burning of the skin. At the same time, changes in the nails and joint pain may be observed.
Psoriasis on the palms and soles of the feet- typical psoriatic rashes appear in the area of the palms and soles, less often they occur in the form of localized pustular psoriasis. It can also affect and deform the nails - they thicken, become cloudy and uneven.
Psoriasis on the palm
Erythrodermic psoriasisIt is quite rare and is considered an extremely serious form of the disease. There is redness on about 90% of the body, intense itching and pain appear, the skin swells and peels. The temperature often rises and the lymph nodes become inflamed.
Typically, this type of psoriasis is the result of an exacerbation of another form of the disease due to inadequate treatment or adverse environmental factors (e. g. , sunburn in advanced psoriasis vulgaris, inappropriate use of external irritants, or intravenous administration of glucocorticosteroids).
Psoriasis symptoms
The manifestations of psoriasis vary depending on the type of disease and its severity.
Common symptoms and signs of psoriasis:
- red, raised, scaly patches on the skin;
- itching in the area of inflammation and peeling;
- changes in the nails: point impressions, thickening and disintegration of the plate, its separation;
- joint pain (sometimes).
For an accurate diagnosis, you need to contact a specialized specialist - a dermatologist.
The mechanism of development of psoriasis
Psoriasis is an autoimmune disease.
All autoimmune pathologies are associated with an error in the functioning of the immune system. Normally, it "scans" the body 24 hours a day and looks for pathogenic cells using foreign protein molecules that distinguish them from the "normal" cells inherent in the body.
As soon as foreign protein molecules are detected, the immune system activates special immune cells - T lymphocytes, which must destroy the enemy.
But for some people, the friend-foe recognition system can fail. As a result, the immune system begins to attack healthy cells in individual organs or tissues, causes inflammation in their locations and harms your body in every possible way, which, in fact, it should protect.
This is what happens with psoriasis: the immune system attacks the skin. It activates T lymphocytes and "fixes" them to skin cells. Upon reaching the goal, T lymphocytes release substances that cause inflammation - cytokines. They cause the first symptoms: redness, swelling, itching and pain.
In psoriasis, skin cells divide several times faster, resulting in scales and peeling.
Under the influence of cytokines, an inflammatory process develops and skin cells begin to actively divide - this is how active peeling occurs and a convex plate is formed.
Since the process of cell renewal accelerates almost tenfold, the main cells of the epidermis (keratinocytes) do not have time to form properly. And therefore, they cannot perform their barrier function.
As a result, the stratum corneum becomes permeable and no longer protects the deeper layers of the skin from the environment and moisture loss. All of this leads to even more inflammation.
Until the immune system calms down, the disease will progress and symptoms will increase.
Causes of psoriasis
The exact reasons why psoriasis develops are not yet fully understood. However, many studies agree that the development of psoriasis is associated with genetics, as well as lifestyle, concomitant diseases and adverse environmental factors.
Genetics
The disease is often inherited from parents to children. Psoriasis is mainly associated with the HLA-C gene. It encodes a protein that allows the immune system to recognize its own (harmless) cells.
In patients with psoriasis, doctors detect a special genetic marker in the HLA-C gene more often than in other people - HLA-Cw6. However, its presence only indicates a predisposition to the disease. Not all people with the HLA-Cw6 marker necessarily have psoriasis, and not all patients diagnosed with the disease have this genetic change.
Lifestyle
It is believed that constant damage to the skin, frequent rubbing, sunburn and hypothermia can be triggers for the development of the disease. Especially if there is a hereditary predisposition in the form of the genetic marker HLA-Cw6 or close relatives suffering from psoriasis.
Other risk factors include constant stress, alcohol abuse and smoking - all of which have a detrimental effect on metabolism, the functioning of internal organs and the immune system.
Concomitant pathologies
Some types of psoriasis, such as guttate psoriasis, may appear after a streptococcal infection.
Furthermore, the risk of developing pathology increases in people with autoimmune diseases. These include, for example, type 1 diabetes, Crohn's disease, systemic lupus erythematosus and rheumatoid arthritis.
In these diseases, the general mechanism of the immune system is disturbed: it perceives some of its own cells as something foreign, reacts with inflammation and destroys them. Consequently, the risk that she will mistakenly add other cells to the "black list" increases.
Complications of psoriasis
Psoriasis is caused by a malfunction of the immune system and chronic systemic inflammation. It develops due to constant aggression by immune system cells against healthy tissues.
Autoimmune processes differ in that they can spread: the immune system is capable of including other healthy cells in the list of "enemies" at any time.
For example, in the context of psoriasis, Crohn's disease or ulcerative colitis can develop if the immune system mistakenly attacks the tissues of the gastrointestinal tract.
In addition to autoimmune diseases, people with psoriasis are susceptible to various endocrine pathologies (metabolic syndrome, obesity, type 2 diabetes), cardiovascular diseases (hypertension, heart attack) and other internal organ dysfunctions. All of this is associated with a chronic inflammatory process that affects hormonal levels and interferes with normal metabolism.
A separate complication is psoriatic arthritis. It occurs in approximately 30% of people with psoriasis.
In psoriatic arthritis, the immune system attacks connective tissue, most often affecting the joints of the lower extremities. Inflammation of the joint structures develops, the skin in the affected area may turn red, swelling appears, as well as pain and/or stiffness when trying to bend or straighten the joint.
In 10% of people with psoriasis, the pathology spreads to the eyes and uveitis develops. The choroid of the eye becomes inflamed, which leads to decreased vision and discomfort.
In addition to physiological complications, psoriasis can affect a person's mental health. Changes in appearance, poor skin condition and unbearable itching can cause doubts and lead to depressive disorder.
Diagnosis of psoriasis
A dermatologist diagnoses skin conditions, including psoriasis.
At your appointment, your doctor will ask about your symptoms and how long ago they started. Then he will ask the closest relatives: parents, brothers and sisters about skin diseases. Family history allows a specialist to immediately assume diseases that can be inherited - psoriasis is one of them.
The doctor will also ask about situations that cause new rashes to appear and symptoms to worsen. For example, new psoriatic lesions may appear after taking a hot shower or prolonged exposure to the sun. In some patients, plaques appear at the injection site, in scratches or after rubbing the skin against clothing - this is how Koebner's phenomenon, characteristic of psoriasis, manifests itself.
An important point in establishing the diagnosis is examination of the rash. If the picture of the disease is insufficient, the specialist can observe the rash over time and prescribe a histological examination of the skin (biopsy).
If the doctor is not sure that the plaques on the skin are psoriasis, he will prescribe a biopsy and a histological examination of the skin.
Histological examination of cutaneous and subcutaneous neoplasms
The study makes it possible to identify malignant changes in the tissues of skin tumors (spots, papillomas, warts, age spots). For analysis, material obtained through biopsy or during surgery is used.
In some cases, a specialist can check the psoriatic triad, the main diagnostic signs of psoriasis.
First, the dermatologist will take a glass slide or scalpel and begin to gently scrape the surface of the plaque. The slight exfoliation of whitish scales from its surface, or stearin stain phenomenon, is the first sign of the triad.
After all crusts are removed, the surface of the plate becomes smooth, shiny and slightly damp. This is the second sign of the triad - terminal film.
If the doctor continues to scratch the spot, pinpoint bleeding will appear on its surface, which is called Auspitz syndrome, or bloody dew, the third sign of the psoriatic triad.
After an examination and medical history, the doctor will prescribe laboratory tests. It is generally recommended to have a clinical blood test - it reflects the general state of health. The patient is also referred for blood chemistry. It allows you to assess the functioning of internal organs and metabolism - with a long course, psoriasis can provoke pathologies of the cardiovascular and endocrine systems.
A general urine test is also often prescribed. Disorders associated with the urinary system may interfere with the prescription of certain medications.
A general urine test includes a physical and chemical examination of urine (color, density, composition) and a microscopic examination of its sediment. A general urine test is prescribed to check the condition of the body, to identify pathologies of the urinary system, gastrointestinal tract, endocrine, infectious and inflammatory diseases.
For the same reason, according to clinical recommendations, tests for HIV and hepatitis are prescribed. Against the background of these infections, the disease can be more serious.
Additionally, in preparation for treatment, women should take a pregnancy test - for example, take a blood test for beta-hCG. The fact is that many systemic drugs, which are most often prescribed for the treatment of psoriasis and have a good effect, are contraindicated during pregnancy.
The study makes it possible to diagnose pregnancy in the early stages and identify its complications. In induced abortion, it is used to evaluate the effectiveness of the procedure. In oncology - to diagnose hormone-producing tumors.
If you complain of joint pain, the doctor will also refer the patient for an MRI, CT scan, or x-ray to confirm or rule out psoriatic arthritis. If joint inflammation is confirmed, the dermatologist will recommend an examination by a rheumatologist.
Psoriasis treatment
If the area of affected skin is small, patients are given topical corticosteroid creams or ointments. They suppress inflammation and reduce the manifestations of the disease.
Additionally, the doctor may prescribe local analogues of vitamin A or vitamin D. These drugs relieve inflammation, accelerate the exfoliation of the stratum corneum of the skin, and slow down the growth of psoriatic plaques. It is also recommended to use skin moisturizers from pharmacy dermatocosmetic lines.
Mild psoriasis is often treated with ointments and creams for external use.
For moderate to severe psoriasis, systemic treatment may be required - in the form of classic immunosuppressants and genetically modified biological medicines in the form of tablets or subcutaneous injections. They have a pronounced effect, but require careful examination before use.
Systemic glucocorticosteroids for psoriasis are contraindicated and can only be prescribed by a doctor in certain (extremely difficult) situations and in a hospital setting. Otherwise, such treatment can lead to a significant deterioration of the condition.
Psoriasis is also treated with phototherapy: ultraviolet light of a certain spectrum is directed at the plaques. Many physical therapy offices have special lamps for this type of treatment.
The most modern and effective way to treat psoriasis is monoclonal antibodies (genetically engineered biological therapy). These medications can block some stages of the inflammatory response, for example, certain cytokines CytokinesProteins, which are mainly produced by the protective cells of the immune system, cause inflammation and plaque growth in psoriasis.
Psoriasis prevention
There is no specific prevention that can prevent the development of psoriasis.
In general, it is recommended to lead a healthy lifestyle: give up alcohol and smoking, exercise and follow a healthy, balanced diet.
People whose family members have psoriasis should be more careful with their skin: moisturize it regularly, avoid hypothermia, prolonged exposure to the sun and also avoid going to solariums. Tattoos are not recommended if you have a hereditary predisposition to psoriasis.
Forecast
Psoriasis is a chronic pathology, like all autoimmune diseases. It is impossible to completely cure psoriasis.
However, timely and properly selected treatment can allow the patient to achieve long-term remission - a period of asymptomatic disease.
FAQ
How is psoriasis transmitted?
Psoriasis cannot be infected. It is an autoimmune disease – it occurs when a person's immune system malfunctions and mistakenly attacks skin cells. The disease has a hereditary (genetic) predisposition, which means it can be hereditary.
How does psoriasis manifest itself?
In most cases of psoriasis, large red, scaly patches appear on the surface of the skin. They can be very itchy and even painful. Most often, psoriatic patches appear on the elbows, knees, torso and scalp.
Which doctor treats psoriasis?
A dermatologist treats psoriasis.
Can people with psoriasis be accepted into the army?
With a mild form of psoriasis, they can be attributed to category B - "limitedly adequate". A recruit with moderate or severe psoriasis may be considered unfit for military service. In each specific case, the decision is made individually during the medical examination.